Injections for knee pain relief are usually administered for knee pain caused by arthritis, since other types of knee pain are often better treated by other methods such as physical therapy, braces, compressions, or chiropractic.

Injections into the knee are performed in an office setting. Ultrasound may be used to confirm the needle placement within the joint.

The injection of numbing medicine along with a natural, plant-based non-steroidal medication is performed to promote healing.  The injection is typically used in combination with physiotherapy, rehabilitation exercises and chiropractic treatment.